The A329M is due to be closed on 10 and 11 April, from 9pm to 6am, between its slip roads with the M4 (junction 10).
The motorway needs to be fully closed so Wokingham Borough Council contractors can do highways maintenance in safety.
Northbound vehicles affected by the closure can go onto the M4 westbound to junction 11, and double back to re-join the A329M. Likewise, southbound vehicles can join the M4 eastbound to junction 8/9, and then double back.
Advanced warning signs will also be in place to allow traffic to take the A329 between Winnersh Triangle and Coppid Beach.
On the 12, 13 and 14 April overnight work will continue, between 9am and 6am, with lane closures only – not the entire carriageway.